Cox-2 Inhibitors Increase Heart Rate in Daphnia Magna
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چکیده
In this investigation, I set out to confirm or possibly disprove the notion that Cyclooxygenase-2 (Cox-2) inhibitors causes increased cardiovascular (CV) risk. To state my objective more precisely, I wanted to find a relationship between hear rate and concentration that would look like a y = IxI (these bars are the absolute value notation) graph where x> 0 (“x” being concentration, and “y” being heart rate). All the tests were performed using Daphnia Magna to observe physiological state and also to test heart rates. Essentially, two different types of were tested. The daphnia were given doses of Celebrex ranging from one to three days; and furthermore, a control was tested in range from one to three days in distilled water. The results were essentially that Cox2 increased heart rate significantly in higher doses; however, in these higher doses, the daphnia did not live longer than two days at the most. This process was repeated with different concentrations however those results were inconclusive.
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تاریخ انتشار 2006